A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001

• Rattiya Janthanom,
• Yuta Kikuchi,
• Hiroki Kanto,
• Tomoyasu Hirose,
• Arisu Tahara,
• Takahiro Ishii,
• Arinthip Thamchaipenet and
• Yuki Inahashi

Beilstein J. Org. Chem. 2024, 20, 497–503, doi:10.3762/bjoc.20.44

• metabolites from the rare actinomycete Saccharopolyspora sp. KR21-0001. As a result, KR21-0001A (1), a new analog of dihydroxybenzoic acid, was discovered as a potent antioxidant. In conclusion, exploring rare actinomycetes for bioactive compound discovery represents a promising way in the quest for new drugs

Identification of the p-coumaric acid biosynthetic gene cluster in Kutzneria albida: insights into the diazotization-dependent deamination pathway

• Seiji Kawai,
• Akito Yamada,
• Yohei Katsuyama and
• Yasuo Ohnishi

Beilstein J. Org. Chem. 2024, 20, 1–11, doi:10.3762/bjoc.20.1

• in Supporting Information File 1, and Table 1). We anticipated that they would be a subtype of ava-like BGCs and might produce compounds other than avenalumic acid. Among these clusters, we focused on a cluster present in the genome of a rare actinomycete, Kutzneria albida, and named it as cma

• diazo group-containing compounds through directed evolution. Finally, this study is important because of the success of genome mining for BGCs in a rare actinomycete, K. albida. Although 47 BGCs were indicated in the K. albida genome by the antiSMASH analysis, only aculeximycin was reported as a natural

Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes

• Shun Saito,
• Kanji Indo,
• Naoya Oku,
• Hisayuki Komaki,
• Masashi Kawasaki and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2939–2949, doi:10.3762/bjoc.17.203

• were weakly inhibitory against Kocuria rhizophila at MIC 100 μg/mL and none were cytotoxic against P388 at the same concentration. Keywords: Couchioplanes; prenylated tryptophan; rare actinomycete; unsaturated fatty acid; Introduction Actinomycetes, a subgroup of filamentous Gram-positive bacteria

Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura

• Zhiwei Zhang,
• Tao Zhou,
• Taehui Yang,
• Keisuke Fukaya,
• Enjuro Harunari,
• Shun Saito,
• Katsuhisa Yamada,
• Chiaki Imada,
• Daisuke Urabe and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2194–2202, doi:10.3762/bjoc.17.141

• , an antibacterial oxime derivative from Micromonospora [14]. Along the lines of these previous studies, metabolite analysis of actinomycetes from the DSW of Sagami Bay was further conducted, and three new tetronate-class polyketides, nomimicins B (1), C (2), and D (3) were found from a rare

• actinomycete of the genus Actinomadura. We herein describe the isolation, structure determination, and biological activities of 1‒3. Results and Discussion The producing strain Actinomadura sp. AKA43 was isolated from DSW collected at a depth of −800 m in Sagami Bay, Japan. Strain AKA43 was cultured in A16

The regulation and biosynthesis of antimycins

• Ryan F. Seipke and
• Matthew I. Hutchings

Beilstein J. Org. Chem. 2013, 9, 2556–2563, doi:10.3762/bjoc.9.290

• antAB and antCDE is a transcriptional activator that is encoded outside of the ant gene cluster and is absent from the heterologous host strains (Seipke and Hutchings, unpublished results). Regulation of antibiotic gene clusters by ECF σ factors has only been reported in two rare actinomycete strains